Gpatch domain and kow motifscontaining protein, gpkow ncbi. Using yeast twohybrid screening with the pka c subunit cbeta2 as bait, we identified the gpatch domain and kow motifscontaining protein. Mos2, a protein containing gpatch and kow motifs, is essential for. Structures and functions of the multiple kow domains of. The major human spliceosome contains 45 distinct proteins in its snrnp.
Gpkow is a nuclear protein that regulated by catalytic c subunit of protein kinase a pka and bind rna in vivo. The biology of rnaprotein complexes universitat regensburg. Arabidopsis vq motifcontaining proteins have recently been demonstrated to interact with several wrky transcription factors. Gpkow is a nuclear protein with three nucleic acid binding domains, one gpatch domain and two kowmotifs. We have demonstrated that gpkow binds rna in vivo and that gpkow associate with c. Gpatch2 g patch domain containing 2 is a protein coding gene. Loc102890286 g patch domain and kow motifscontaining. Gpatch2 gene genecards gptc2 protein gptc2 antibody. The short motifs lying on the distal ends of the disordered linkers are.
Gpatch11 is a protein that in humans is encoded by the g patch domain containing protein 11 gene. Identification of droughtresponsive universal stress proteins in viridiplantae article pdf available in bioinformatics and biology insights 55. Gpatch domain and kow motifscontaining protein, gpkow. Gpatch domain ipr000467 interpro entry interpro emblebi. Gpkows ability to bind rna is regulated by pkadependent phosphorylation at two sites. Kow motif of the g patch domain and kow motifscontaining protein gpkow repeat b gpkow contains one g patch domain and two kow motifs. The protein has been found to interact with several other proteins, including two from a splicing pathway. Sugp1 surp and gpatch domaincontaining protein 1 homo. Gpkow gpatch domain and kow motifscontaining protein. Arabidopsis snc1 encodes a tirnbslrrtype r protein with a similar structure to nucleotide binding oligomerization domain nod proteins in animals. Deletions of intronic region containing m6alinked drach motif resulted in partial diminution of. Loc102890286 g patch domain and kow motifscontaining protein black flying fox gene id. Using yeast twohybrid screening with the pka c subunit cbeta2 as bait, we identified the gpatch domain and kow motifscontaining protein gpkow, also known as the t54 protein or mos2 homolog, as an interaction partner for cbeta2.
In contrast, the archaeal and bacterial proteins contain only a single cterminal kow domain without a ctrlike tail see fig. Diseases associated with gpatch2 include lymphogranuloma venereum and granuloma inguinale. In eukaryotes, the remainder of the central region between the ngn and the ctr contains five kow motifcontaining domains. An example hereof is the processing of the gpatch domainand kow motif containing t54 protein. Structural bioinformatics of the human spliceosomal proteome.
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